Upaya Naturals -Breast Plex - 60 Veg Caps) Bio Response DIM

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Breast Plex - 60 Veg Caps) Bio Response DIM

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Product Code: RXB-285

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Description

Breast Plex - (60 Veg Caps)
with Bio Response DIM

Formula Rationale:
Diindolylmethane (DIM) supports specific enzymes that improve estrogen metabolism. RxBalanceTM Breast-Plex uses BioResponse DIM®, the only patented, absorption enhanced formulation for DIM. BioResponse DIM® combines vitamin E and phosphatidylcholine with DIM, and then micro-encapsulates the combination to deliver enhanced bioavailablity. DIM is an indole plant nutrient found in cruciferous vegetables such as broccoli, cabbage, Brussels sprouts, and cauliflower. Unlike other plant nutrients, such
as soy isoflavones, DIM has been shown to have unique and distinct hormonal benefits, including its ability to increase the level of “good” estrogens (2-hydroxy estrogen), while reducing the level of “bad” estrogens (16-hydroxy estrogen). An increased proportion of 2-hydroxy metabolites is correlated with protection from familial risk of breast cancer, uterine cancer, cervical cancer, and systemic lupus erythematosis. Low 2-hydroxy estrogen production is also associated with mid-life weight gain, cyclical mastalgia,
obesity, and elevated systolic blood pressure in otherwise healthy post-menopausal women. Several studies indicate that DIM provides potential protection against hormone dependent cancers, and that it is a potent stimulator of immune function, which might contribute to the cancer inhibitory effects of this indole.5

Dr. Crisafi’s comments:
Hyperestrogenism is the term used to describe excess estrogen and its effects. The excess of estrogen may be due to excessive production or intake of estrogen or inappropriate or defective breakdown or reabsorption from the gastro-intestinal tract. Though symptoms of excess estrogen are many, the most frequent include: Cyclical mastalgia, endometriosis, excessive menstrual haemorrhaging,
fibrocystic breast disease, uterine fibroids and the premenstrual tension syndrome commonly referred to as
PMS. Extreme conditions associated with hyperestrogenism include breast and uterine cancer.

Unfortunately, the incidence of hyperestrogen related disorders is increasing due to the increase in endogenous estrogen production, estrogen consumption as well as to the accrued presence of estrogen-like substances reffered to as xenoestrogens. Xenoestrogens have been introduced
into the environment by industrial, agricultural and chemical companies only in the last 60 years or so. These include various compounds such as BPA as well as hormone residues in foods such as dairy.

My clinical experience over the last 30 years or so has convinced me – and research over the last 10 years has confirmed – that many women with ovarian, cervical or breast cancers had preliminary symptoms of hyperstrogenism long before developing the cancer themselves. Reducing hyperestrogenism and therefore its symptoms such as mastalgia, helps reduce the incidence of these potentially fatal diseases by reducing their most controlable cause – excess estrogen.

Though much was said in the 1980’s about the role of betacarotene-containing foods such as broccoli in reducing breast cancer risk, research is now highlighting the effects of compounds other than carotenoids in these positive effects. Around 170 BC, Cato the Elder suggested that if a cancerous ulcer appeared on a breast, applying a crushed cabbage leaf would make it better. Research now highlights the very
potent effects of indoles, of which diindolylmethane (DIM) is the most biologically potent.

Unfortunately, it is not always practical, feasible or even advisable, to consume large amounts of cruciferous
vegetables to improve potential hyperestrogenism. This is due to a certain number of constraining factors. Firstly, if the cruciferous vegetables are not organically grown, the pesticide residues (virtually all of which are identified as xenoestrogens) could actually have a counterproductive effect of supplying excess estrogen. Secondly, in many individuals the gastro-intestinal symptoms triggered by the consumption
of cruciferous vegetables can be very limiting. Finally, the sheer amount of cruciferous vegetables required to ensure a sufficient intake of therapeutically active indoles may limit the possibility of consuming enough on a daily basis.

At our clinic DIM is used successfully to reduce the symptoms as well as the causes of premenstrual tension syndrome (PMS or PMT), endometriosis and other hyperestrogen related disorders. We also use DIM preventatively in patients who have a greater risk of breast cancer because of individual genetic, dietary or lifestyle factors.

RxBalanceTM Breast-Plex has the advantage of supplying the most biologically active form of indoles in a synergistic complex in an effective, clinically proven, delivery form. The microencapsulation of DIM along with its synergists, vitamin E and phosphatidylcholine, gives consistent clinical results.

Ingredients:
Each capsule contains:
BioResponse DIM®.................................................................. 120 mg
providing:
3,3'-Diindolylmethane......................................30 mg
Vitamin E (d-alpha tocopheryl succinate)....7.37 mg AT/11 IU
Phosphatidylcholine (Glycine max seed)........................5 mg

Non-medicinal ingredients:
Cellulose, corn starch, silicon dioxide, stearic acid, hypromellose.
This product does not contain dairy, egg, gluten, shellfish, sulfites, animal derivatives, or artificial colours, flavours, or preservatives.

Primary indication(s):
For symptomatic improvement of cyclical mastalgia (recurrent breast pain). Helps in the reduction and
management of cyclical mastalgia symptoms in premenopausal women. Helps in reducing pain associated
with cyclical mastalgia.

Recommended Dose:
Adults: Take 2 capsules daily for three months.
For prolonged use, consult a health care practitioner.

Caution:
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you are trying to conceive or if you have a liver disorder and/or a predisposition to cancer. Consult a health care practitioner prior to use if you are taking prescription medication. Harmless changes in urine colour may occur with the use of this product.

Recommended Dose:
Adults: Take 2 capsules daily for three months.
For prolonged use, consult a health care practitioner.

Complements:
Liv-Tox, Magnesium Bisglycinate, Krill-Plex, Kyo-Dophilus.

Caution:
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you are trying to conceive or if you have a liver disorder and/or a predisposition to cancer. Consult a health care practitioner prior to use if you are taking prescription medication. Harmless changes in urine colour may occur with the use of this product.

Selected References
• Zeligs MA, Brownstone PK, Sharp ME, Weslerlind K, Wilson SM, Johs SM.
Managing cyclical mastalgia with absorbable diindolylmethane: a randomized,
placebo-controlled trial. JANA. 2005;8(1):10–20.
• Fares F, Azzam N, Appel B, Fares B, Stein A. The potential efficacy of
3,3'-diindolylmethane in prevention of prostate cancer development.
Eur J Cancer Prev. 2010;19(3):199–203.
• Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Pilot study:
effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in
postmenopausal women with a history of early-stage breast cancer.
Nutr Cancer. 2004;50(2):161–157.
• Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjedanes LF. Activation
and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in
MCF-7 breast cancer cells. Mol Pharmacol. 2006;69(2):430–439.
• Xue L, Pestka JJ, Li M, Firestone GL, Bjeldanes LF. 3,3'-Diindolylmethane
stimulates murine immune function in vitro and in vivo. J Nutr Biochem.
2008;19(5):336–344.
• Terry P, Wolk A, Persson I, Magnusson C (2001). "Brassica Vegetables and
Breast Cancer Risk". JAMA the Journal of the American Medical Association.
285 (23): 2975–2976.
• Genkinger JM, Hunter DJ, Spiegelman D, et al. Dairy products and ovarian
cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev.
2006; 15:364–72.
• Ganmaa D, Sato A. The possible role of female sex hormones in milk from
pregnant cows in the development of breast, ovarian, and corpus uteri cancers.
Med Hypotheses. 2005;65:1028–37.

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